Acylating Agent · Organic Acid Anhydride
Propionic Anhydride
(Propanoic Anhydride / Propionic Acid Anhydride / Propionyl Anhydride)
| CAS Nr. | 123-62-6 |
| IUPAC npe | propanoic anhydride hmoov |
| Synonyms | Propionic acid anhydride, propanoic acid anhydride, dipropanoyl oxide, propionyl anhydride, propyl anhydride |
| Molecular Formula | (CH₃CH₂CO)₂O / C₆H₁₀O₃ |
| Molecular Luj | 130.14 g / mol |
| HS Code | 2915400000 |
| Qib Muaj | Qib Industrial Pharmaceutical Qib |
Propionic Anhydride yog dab tsi? Ib qho kev nthuav dav
Propionic anhydride(tseem hu ua propanoic anhydride lossis propionic acid anhydride, CAS 123-62-6) yog cov kua tsis muaj xim, pungent kua nrog cov mis molecular (CH₃CH₂CO)₂O. Nws yog anhydride ntawm propionic acid (propanoic acid), tsim los ntawm condensation ntawm ob propionic acid molecules nrog tshem tawm dej. Nws reactive anhydride daim ntawv cog lus ua rau nws ua tau zoo heevacylating tus neeg sawv cev- nws yooj yim qhia propionyl pawg rau hauv cov molecules bearing hydroxyl (–OH), amino (–NH₂), thiab lwm pab pawg nucleophilic ua haujlwm nyob rau hauv cov mob me.
Piv rau propionic acid nws tus kheej, propionic anhydride reacts sai dua thiab ntau dua tag nrho, tsim propionic acid raws li tib yam los ntawm - khoom - ib tug tseem ceeb kom zoo dua acyl chlorides (uas tsim HCl) nyob rau hauv cov tshuaj thiab zaub mov- cov ntawv thov qib. Piv rauacetic anhydride(acetic propionic anhydride cov tshuaj tiv thaiv), propionic anhydride teeb tsa peb -carbon propionyl saw, muab cov khoom sib txawv physicochemical zog xws li txhim kho lipophilicity thiab metabolic stability.
Peb koom tes nrog cov tuam txhab lag luam hauv Suav teb siv cov khoom siv txuas ntxiv propionic acid condensation thiab ntau -theem distillation purification technology los muab Cov Qib Siab (Ntau dua lossis sib npaug li 99.0%) thiab Pharmaceutical Qib (Ntau dua lossis sib npaug li 99.5%) propionic anhydride ntawm cov nqi sib tw, nrog cov ntim ntim tau yooj yim los ntawm 200 kgs rau cov tsheb thauj khoom hauv Europe, cov khoom siv hluav taws xob sab qaum teb thiab cov khoom siv hluav taws xob. America, Southeast Asia, thiab Middle East.
Physical & Chemical Properties of Propionic Anhydride
Propionic Anhydride Specifications - Muaj & Pharmaceutical Qib
| Khoom Specification | Qib Industrial Agrochemical / Polymer / Flavor |
Pharmaceutical Qib API Synthesis / GMP |
|---|---|---|
| Qhov tshwm sim | Colorless pob tshab kua, tsis pom impurities | Colorless pob tshab kua, tsis muaj teeb meem tshem tawm |
| Purity (GC) | Ntau dua lossis sib npaug li 99.0% | Ntau dua lossis sib npaug li 99.5% |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 0.1% | Tsawg dua lossis sib npaug li 0.05% |
| Xim (Pt-Co) | Tsawg dua los yog sib npaug li 10 | Tsawg dua los yog sib npaug li 5 |
| Boiling Point | 167-169 degree | 167.5–168.5 degree |
| Lub ntiajteb txawj nqus tshwj xeeb (20 degree) | 1.015–1.019 g/cm³ | 1.016–1.018 g/cm³ |
| Refractive Index (20 degree) | 1.403–1.405 | 1.4035–1.4045 |
| Cia ruaj khov | 12 lub hlis ( kaw, txias<30°C) | 18 lub hlis ( kaw, 5-25 degree, tsaus) |
| Ntim | 200 kg steel nruas 1000 kg IBC tote Tank tsheb |
200 kg sealed steel nruas IBC tote (N₂{0}}pam) |
Ua raws li ISO, REACH, ICH Q3C cov lus qhia. COA, SDS/MSDS, thiab thib peb -cov ntaub ntawv kuaj xyuas tog muaj nyob rau ntawm kev thov.
Kev siv Propionic Anhydride & Kev siv
1. Pharmaceutical Industry - API Synthesis & Drug Intermediates
Propionic anhydride yog ib qho tseem ceebacylating tus neeg sawv cevhauv kev tsim tshuaj. Nws daim ntawv thov tseem ceeb tshaj plaws yog nyob rau hauv synthesis ntawmpropionic acid{0}} muab NSAIDs: nws yog ib qho tseem ceeb nruab nrab hauv kev tsim khoom ntawm Ibuprofen, Naproxen, thiab Ketoprofen, qhov uas nws ua tau zoo qhia cov pab pawg propionyl nyob rau hauv cov mob me, tswj tau nrog cov txiaj ntsig siab thiab cov tshuaj tiv thaiv tsawg tsawg. Nws kuj tseem siv rau hauv kev sib txuas ntawm cov tshuaj tiv thaiv - tshuaj tiv thaiv kab mob vwm, tshuaj tiv thaiv kab mob, thiab tshuaj tua kab mob nruab nrab.
Pharmaceutical-qib propionic anhydride (Ntau dua lossis sib npaug rau 99.5%) raws liGMP thiab ICH Q3Cresidual solvent cov lus qhia, xyuas kom meej tias cov tshuaj yeeb tshuaj zaum kawg ua raws li Ph Eur, USP, thiab BP pharmacopoeia cov qauv. Los ntawm - cov khoom propionic acid tsis yog - tshuaj lom thiab tshem tawm yooj yim los ntawm kev ntxuav lossis distillation, ua kom yooj yim rau hauv qab dej kom huv.
2. Kev lag luam Agrochemical - Tshuaj tua kab mob, tshuaj tua kab mob thiab kev loj hlob Regulators
Hauv agrochemical sector, propionic anhydride yog qhov tseem ceeb rau kev tsim khoompropionamide-raws li tshuaj tua kab, tshuaj tua kab, thiab tshuaj tua kab mob. Nws yog siv los ua acylate amine intermediates nyob rau hauv herbicide synthesis, txhim kho cov kev ua si lom neeg thiab ib puag ncig xaiv ntawm cov khoom xyaw kawg. Nws kuj tseem ua haujlwm hauv kev sib txuas ntawm cov tswj kev loj hlob ntawm cov nroj tsuag (PGRs), txhim kho cov qoob loo tawm los thiab tom qab- khaws cia ruaj khov.
Nws cov reactivity siab thiab huv si los ntawm -product profile (propionic acid nkaus xwb) ua rau nws nyiam acylating tus neeg sawv cev tshaj propionyl chloride rau loj -scale agrochemical synthesis, txo corrosion thiab pov tseg cov nqi kho mob.
3. Flavor & Fragrance Industry - Propionate Esters & Lactones
Propionic anhydride yog dav siv hauv kev lag luam tsw los ua kepropionate esters muaj- suav nrog methyl propionate, ethyl propionate, thiab lwm yam txiv hmab txiv ntoo/creamy esters - thiab lactones uas ua rau cov txiv hmab txiv ntoo, buttery, thiab qab zib sau ntawv rau zaub mov, dej haus, thiab tshuaj pleev ib ce. Raws li acylating catalyst thiab esterification tus neeg sawv cev, nws txhim kho cov txiaj ntsig thiab purity ntawm propionate tsw tshuaj thaum lub rooj sib thamFCC (Food Chemicals Codex) thiab FAO/WHOcov qauv rau zaub mov-hu rau daim ntawv thov.
4. Cellulose & Polymer Kev Lag Luam - Cellulose Acetate Propionate (CAP)
Ib qho tseem ceeb tshaj plaws kev lag luam siv ntawm propionic anhydride yog kev tsim khoomCellulose acetate propionate (CAP) hmoov, high -kev ua tau zoo thermoplastic polymer. Nyob rau hauv CAP synthesis, propionic anhydride reacts nrog cellulose nrog rau acetic anhydride los qhia ob qho tib si acetyl thiab propionyl substituents, yielding ib tug polymer nrog zoo heev optical transparency, tej yam kuj, thiab UV stability. CAP yog dav siv nyob rau hauvoptical films, automotive interior coatings, inkjet coatings, thiab tshwj xeeb ntim.
Propionic anhydride kuj hloov lwm yam polymers (polyvinyl cawv, starch) los txhim kho hydrophobicity, tshav kub tsis kam, thiab processability - nthuav nws lub luag hauj lwm nyob rau hauv tshwj xeeb coatings thiab biodegradable cov ntaub ntawv.
5. Lwm cov ntawv thov kev lag luam - Dyes, Rubber & Surface Treatment
Propionic anhydride ua raws li qhov nruab nrab thiab hnyav hauv kev sib txuas ntawmdyes, pigments, thiab roj hmab chemicals, qhov twg nws muaj peev xwm acylation ua kom meej molecular hloov kho ntawm chromophores thiab cross -linking agents. Hauvhlau nto kho thiab electroplating, nws txhim kho txheej adhesion los ntawm propionylation ntawm hydroxyl pawg.
Nws kuj yog siv los ua cov tshuaj tiv thaiv nruab nrab thiab nruab nrab hauv kev tsim cov khoom tshwj xeeb lubricant additives thiab hauv covPropionic anhydride synthesisntawm nplua chemical tsev blocks siv thoob plaws cov tshuaj tshwj xeeb sector.
Propionic Anhydride Ua li cas? Synthesis Txheej txheem cej luam
Propionic anhydride yog tsim los ntawm kev lag luamPropionic acid lub cev qhuav dej / condensation. Lub hauv paus kev lag luam yog cov tshuaj tiv thaiv ntawm propionic acid nrog lub cev qhuav dej los yog ketene sib npaug, los yog los ntawm cov tshuaj tiv thaiv nrog acetic anhydride ua raws li fractional distillation kom cais cov ntshiab propionic anhydride. Ib qho sib xyaw anhydride (acetic propionic anhydride) tuaj yeem tsim ua ib qho nruab nrab hauv cov txheej txheem no. Lwm txoj hauv kev muaj cov tshuaj tiv thaiv ntawmpropionyl chloride nrog sodium propionate.
Peb cov kws tsim khoom lag luam siv cov kab txuas txuas txuas ntxiv nrog ntau -theem fractional distillation kom ua tiav purity Ntau dua lossis sib npaug li 99.0-99.5%, nrog kev tswj nruj tshaj li cov residual propionic acid, dej cov ntsiab lus, thiab xim Performance index kom tau raws li kev lag luam thiab tshuaj - qib specifications.
Cia, ruaj khov & kev nyab xeeb tuav ntawm Propionic Anhydride
Kev Cia Siab
Khw hauv atxias, qhuav, zoo -ventilated warehousentawm 5-30 degree, deb ntawm lub hnub ncaj qha, tshav kub qhov chaw, thiab qhib nplaim taws. Siv cov nruas hlau los yog IBC totes. Khaws kom deb ntawm dej, muaj zog acids, muaj zog hauv paus, thiab oxidizers. Khaws cia nyias ntawm cov khoom noj thiab tshuaj los tiv thaiv kev sib kis -. Cov pawg ntau tshaj: 3 txheej rau 200 kg steel nruas. Lub tsev khaws khoom yuav tsum tau nruab nrog tawg- pov thawj hluav taws xob fittings thiab kev tua hluav taws tsim nyog (cov hmoov qhuav lossis CO₂ - tsis txhob siv dej).
Kev ruaj ntseg ceeb toom
Propionic anhydride yog noo noo-sensitive thiabhydrolyzes ntawm kev sib cuag nrog dej, hloov mus rau propionic acid. Tightly kaw cov thawv tom qab siv txhua zaus. Tsis txhob muaj nitrogen pam vov rau cov qauv kev lag luam qib; nitrogen-pam ntim tau pom zoo rau qib tshuaj los tiv thaiv ob qho tib si noo noo thiab oxidation dhau lub txee lub neej 18-hli.
Kev Nyab Xeeb & Kev Ua Haujlwm (SDS / MSDS Summary)
GHS kev faib tawm:Corrosive rau daim tawv nqaij (Qeb 1), qhov muag loj (Qeb 1), teeb meem yog nqus tau (Qeb 4). UN tus lej: UN 2215 (Class 8, corrosive kua).
Yuav tsum muaj PPE:Tshuaj-cov hnab looj tes tiv taus (nitrile lossis neoprene), tshuaj txhuam tsom iav, lub ntsej muag tiv thaiv, acid/base-cov tshuaj tiv thaiv lab lub tsho tiv no. Ua hauj lwm hauv fume hood los yog yuam kom tso pa tawm hauv zos. Tsis txhob kov txhua daim tawv nqaij thiab qhov muag.
Spill response:Tsis txhob haus dej - siv xuab zeb los yog cov pa roj carbon activated kom nqus cov nchuav. Hloov mus rau cov thawv ntim khoom pov tseg. Neutralize residue nrog dilute sodium carbonate tov ua ntej pov tseg zaum kawg. Tsis txhob tso tawm rau cov kav dej.
Thawj pab:Daim tawv nqaij - tshem tawm cov khaub ncaws tsis huv, yaug nrog dej ntau dua lossis sib npaug li 15 feeb. Qhov muag - yaug nrog dej Ntau dua lossis sib npaug li 15 feeb, nrhiav kev kho qhov muag thaum muaj xwm ceev. Inhalation - txav mus rau huab cua ntshiab. Tag nrho SDS / MSDS PDF muaj los ntawm peb pab pawg muag khoom.
Propionic Anhydride Nqe - 2025 Kev Ua Lag Luam
CovPropionic anhydride nqifeem ntau yog tsav los ntawm feedstock propionic acid nqi thiab xaj ntim. Cov hauv qab no yog qhov qhia txog 2025 tus nqi siv rau Tuam Tshoj- cov khoom hauv paus (ex- ua haujlwm hauv paus):
Cov lus nug nquag nug txog Propionic Anhydride
Q: CAS tus lej rau propionic anhydride yog dab tsi?
CAS tus lej rau propionic anhydride (propanoic anhydride) yog123-62-6. Nws kuj tau sau npe ua CAS 123-62-6 raws li nws lub npe IUPAC propanoic anhydride thiab cov lus sib txuas nrog rau propionic acid anhydride thiab dipropanoyl oxide. Tus lej CAS no siv rau cov khoom siv dawb huv (CH₃CH₂CO)₂O thiab yuav tsum tau teev nyob rau hauv tag nrho cov ntaub ntawv kev yuav khoom thiab kev lis kev cai.
Q: Qhov txawv ntawm propionic anhydride thiab acetic anhydride yog dab tsi?
Ob leeg yog cov organic acid anhydrides thiab acylating agents, tab sis lawv txawv nyob rau hauv pab pawg neeg lawv qhia:acetic anhydrideqhia txog 2-carbon acetyl pawg (CH₃CO–), thaumpropionic anhydrideqhia txog 3-carbon propionyl pawg (CH₃CH₂CO–). Cov pa roj carbon ntxiv hauv cov khoom propionyl nce lipophilicity, uas yog ib qho tseem ceeb hauv kev tsim tshuaj (kev txhim kho daim nyias nyias) thiab tsw chemistry (qhov sib txawv aroma profiles). Acetic anhydride yog ntau reactive thiab qis nqi; propionic anhydride yog qhov zoo dua thaum cov saw hlau propionyl tshwj xeeb yuav tsum tau los ntawm lub hom phiaj molecule qauv. Ib qho kev sib xyaw anhydride -acetic propionic anhydride- cov ntaub ntawv ua ib qho nruab nrab nruab nrab thaum ob lub anhydrides sib xyaw ua ke, thiab tuaj yeem siv los ua cov cuab yeej xaiv acylating.
Q: Puas yog propionic anhydride tib yam li propanoic anhydride?
Yog - lawv zoo ib yam.Propionic acidyog ib txwm siv lub npe, thaumpropanic acidyog lub npe IUPAC systematic rau CH₃CH₂COOH. Raws li, lawv cov anhydride yog raug hu ua "propionic anhydride" thiab "propanoic anhydride." Ib yam li ntawd, cov ntsiab luspropanoic acid anhydridethiabpropionic acid anhydrideyog interchangeable. Txhua tus xa mus rau CAS 123-62-6, molecular formula C₆H₁₀O₃.
Q: Dab tsi yog qhov kev siv tseem ceeb ntawm propionic anhydride hauv cov tshuaj?
Hauv kev tsim tshuaj, propionic anhydride feem ntau yog siv los ua tus neeg sawv cev propionylation rau kev sib txuas ntawm: (1) NSAID cov tshuaj - Ibuprofen (ntawm cov txheej txheem Hoechst-Celanese lossis BHC), Naproxen, thiab Ketoprofen txhua tus koom nrog propionic acid derivatives; propionic anhydride zoo txhim kho propionyl pawg hauv cov kauj ruam tseem ceeb nruab nrab. (2) Steroid derivatives - propionylation ntawm hydroxyl pawg hauv steroidal APIs. (3) Antibiotic intermediates - acylation ntawm amine pawg hauv beta-lactam thiab macrolide synthesis. Nws huv los ntawm -product profile (tsuas yog propionic acid) thiab kev sib raug zoo nrog cov txheej txheem GMP ua rau nws nyiam acylating tus neeg sawv cev tshaj propionyl chloride hauv kev tswj xyuas kev tsim tshuaj.
Q: Dab tsi sib xyaw anhydrides tuaj yeem tsim nrog propionic anhydride?
Propionic anhydride tuaj yeem cuam tshuam nrog lwm cov carboxylic acids lossis lawv cov anhydrides los tsim cov anhydrides sib xyaw. Cov piv txwv tseem ceeb:acetic propionic anhydride(los ntawm acetic anhydride + propionic acid lossis propionic anhydride + acetic acid) - siv los ua tus neeg sawv cev xaiv acylating;formic propionic anhydride- siv nyob rau hauv cov tshuaj tiv thaiv formylation;benzoic propanoic anhydride hmoov- sib xyaw benzoic/propionic anhydride rau xaiv acylation ntawm tsawg reactive substrates;butyric propionic anhydride- rau kev sib xyaw ntawm cov khoom sib xyaw ester polymers. Cov anhydrides sib xyaw no feem ntau yog npaj rau hauv qhov chaw tsis yog cais tawm, siv propionic anhydride ua cov khoom pib.
Q: Qhov kev faib tawm ntawm propionic anhydride SDS / MSDS yog dab tsi?
Cov ntsiab lus tseem ceeb SDS tseem ceeb: GHS kev faib tawm phom sij - Cov tawv nqaij Corrosion/Irritation Qeb 1 (ua rau kub hnyiab heev), Kev puas tsuaj rau qhov muag loj qeb 1, mob toxicity (inhalation) Qeb 4, Flammable Liquid Qeb 3 (flash point 63℃). UN naj npawb: 2215, Chav 8 (corrosive kua), Packing Group II. Khaws kom deb ntawm noo noo, hauv paus, thiab oxidizers. Thaum muaj hluav taws kub, siv cov hmoov qhuav los yog CO₂ - Tsis txhob siv dej (hydrolysis tso tawm corrosive propionic acid). Tag nrho SDS/MSDS PDF muaj los ntawm sales@sinolookchem.com.
Kev Siv Khoom Siv & Cov Qauv
Cov ntaub ntawv qhia txog physicochemical, toxicology, GHS kev faib tawm, thiab cov ntaub ntawv tswj hwm.
Cov qauv siv thoob ntiaj teb rau kev tshuaj ntsuam xyuas thiab tshuaj reagent -qib propionic anhydride zoo benchmarks.
EU REACH dossier: Kev faib tawm phom sij, raug xwm txheej, thiab kev tswj hwm txoj cai rau European lag luam.
Cov kev cai tswj hwm kev lag luam thoob ntiaj teb tswj hwm acylating tus neeg saib xyuas purity hauv cov tshuaj synthesis.
Tau txais ib nqe lus · Cov Qauv · Kev Pabcuam
Thov Propionic Anhydride Nqe & Muab Khoom
Peb muab Kev Lag Luam thiab Pharmaceutical Qib propionic anhydride (CAS 123-62-6) hauv 200 kg drums, IBC totes, thiab tank tsheb nrog cov nqi sib tw. Tiv tauj peb rau kev txiav txim siab, COA, SDS / MSDS, lossis kev sib tham hauv daim ntawv thov.
Yam khoom: Acetic Anhydride · Propionic Acid · Butyric Anhydride · Lwm yam Organic Acid Anhydrides
Cim npe nrov: Tuam Tshoj propionic anhydride manufacturers, lwm tus neeg
